PeproTech重組人IL-6 Receptor/200-06R
PeproTech重組人IL-6 Receptor/200-06R
PeproTech重組人IL-6 Receptor/200-06R
品牌： PeproTech
產(chǎn)地 ：美國
貨號： 200-06R
規(guī)格：5μg/25μg/1mg
保存條件： -20℃
供應商： 深圳子科生物科技有限公司
數(shù)量： 大量
英文名： Recombinant Human IL-6 Receptor
保質期： 1年以上
Synonyms :
soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126
Description :
IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. The IL-6Rα chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6Rα. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Rα alone. IL-6Rα is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6Rα which consists of only the extracellular domain of the IL-6Rα chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6Rα is a 37.6 kDa protein consisting of the extracellular domain of the IL-6Rα chain (338 amino acid residues).
Catalog #:
200-06R
Source :
HEK 293 cells
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
The ED 50 was determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is ≤ 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Selected References :
Selected List of References Citing This Product
AA Sequence :
LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD
PubMed Link :
IL-6+AND+receptor-alpha
Country of Origin :
USA
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Size A
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5μg
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Size B
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20μg
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5
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Size C
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1mg
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00
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Special Sizes:
Many products can be ordered in custom sizes. Please click here to contact with your request.
Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
